The Beauty Librarian

SENTÉ Labs is a privately held specialty aesthetics company leading the field in the development of differentiated medical grade skincare products based on the science of
glycosaminoglycans. SENTÉ‘s motto is Firm. Elastic. Strong.  The results, given a little patience, are just that.

Glycoproteins are emerging as an essential target for reversing skin aging.  With age, we lose glycoproteins, which leads to loss of firmness and sagging.  A key part of the actions of many glycoproteins is the glycosaminoglycan (GAG) side chain. Glycosaminoglycans (GAGs) used to be considered inert molecules restricted in their functioning to space filling during the orientation and organization of the extracellular matrix (ECM), but recent advances have begun to reveal their huge importance (e.g. in regulating inflammation, wound healing, and tissue repair), such that a recent article named them “the unsung heroes of biomolecular signaling.”  It turns out that glycoproteins and GAGs are essential for life and play key roles in tissue remodeling, cell adhesion, growth factor responsiveness, and immune function

When it comes to GAGs, most consumers will be most familiar with hyaluronic acid (HA), which holds a great deal of water, leading to its inclusion in countless skin care products as well as injectable fillers.  However, despite HA’s renown, it actually has far less biological activity than another GAG, heparan sulfate.  Heparan sulfate is present in all layers of skin and—due to its key actions in skin health and wound repair–has been termed a “master molecule” for skin.  For instance, heparan sulfate can bind and interact with extracellular matrix molecules, collagen types I, III, IV, and V, growth factors and cytokines (the basis of stem cell skin care lines), elastase, and much more (see Gallo, 2000). Heparan sulfate also plays a major role in tissue
remodeling, cell adhesion, immune function, and growth factor responsiveness. With age, our levels of heparan sulfate decline, and our skin sags, collagen becomes less organized, and wounds heal more slowly.  Replenishing this vital molecule is likely to have a myriad of marked benefits for aging skin.

Only one cosmeceutical company utilizes heparan sulfate in their products: SENTÉ Labs.  SENTÉ features a patent-pending low-molecular-weight (LMW) heparan sulfate molecule.  Using Heparan Sulfate Analog (HSA) Technology, their product line features a modified form of endogenous heparan sulfate (HS), in which molecular shape, size, and charge were optimized to improve the appearance of mature, photo-aged and dehydrated skin. The benefits have been proven.

SENTÉ’s topical product line with HSA:  penetrates the epidermis, basement membrane, and dermis within 24 hours of application.  An 8-week study demonstrated that SENTÉ’s topical formulation significantly improved: skin hydration, barrier function, elasticity, and fine lines and wrinkles within 8 weeks.  If that is not enough, other research suggests that with its proprietary HSA, SENTÉ products also have: soothing and wound-healing properties and antioxidant properties stronger than vitamin C, as well as anecdotal reports of skin lightening and
brightening effects.

Both products are extremely light, quickly absorbed, and leave no residue behind.  Most anti-aging strategies either completely backfire on skin like mine or offer some temporary
result with no lasting improvement. The irritation-free results I am getting from SENTÉ Bio Complete Serum and Dermal Repair Cream surpass just about everything
else I have tried (which is quite a collection). My skin tends to be pathologically dry, and SENTÉ is the first line ever to make a difference in my skin from the inside (rather than just a
superficial difference). Irritation and dryness are problems of the past. By effectively creating hydration within, my skin is becoming plumped and firmer. With ongoing use, I am watching SENTÉ Bio Cellular Serum and Dermal Repair Cream tackle both sagging and wrinkles, almost like I am getting gradual internal “filler” in all those sagging, droopy spots and areas of entrenched wrinkles. I noticed the first visible difference within just a few days of consistent application, and the results are still coming. More than temporary, superficial changes, my skin also just feels and looks better.  I have experienced no irritation—in fact, the opposite—SENTÉ has been healing for my skin, as well as highly effective in tackling signs of aging.  This is a remarkable, groundbreaking product line, and I give SENTÉ my highest recommendation.